Pittsburgh college professor Grady Tripp is currently single following his divorce from his third wife. After publishing an acclaimed first novel, he's sidelined by a severe case of writer's block. On top of everything else, his affair with one of the (married) chancellors at the university, has resulted in her pregnancy. This often humorous tale of hopes and dreams is based on the bestselling novel by Michael Chabon and features an all-star cast with wonderous chemistry.