Medellin in 1989 was a notoriously dangerous place where drug barons employed teenagers, known as sicarios, to do their killing. Rosario (Martinez) is rushed to a hospital by Antonio (Spanish thesp Unax Ugalde). The story flashes back to introverted Antonio and coke-sniffing rich-kid buddy Emilio (Manolo Cardona) meeting Rosario at a disco. Rosario sees the boys as a way out of the misery of her existence as a high-class hooker and sicario.Rosario shoots a guy who's been hassling her, necessitating the trio make a hasty escape from the disco.
Rosario, a legend among those who know her for her habit of killing her victims while she's kissing them, is sent away with a gringo drug dealer, Donovan (Alex Cox in a typically edgy role). Her bitterness builds still further, and the explosion comes with the death of her sicario brother Johnefe (Rodrigo Oviedo).
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